If your dose is more than 60 units, you will need to give more than one injection. Humalog®, Humalog® Mix50/50™ and Humalog® Mix50/50™ KwikPen® are trademarks of Eli Lilly and Company. Clean the skin as instructed. Injection sites must be rotated to prevent hard lumps from developing at one site. Dose adjustment of Humalog Mix 50 100IU/ml Cartridge may be needed. 3,5,6. Keep HUMALOG Mix50/50 and all medicines out of reach of children. Insulin Lispro+Insulin Lispro Protamine. Never Share a HUMALOG Mix50/50 KwikPen or Syringe Between Patients. Humalog Mix 50 100IU/ml Cartridge is a combination of two medicines used to improve blood sugar control in people with type 1 and type 2 diabetes mellitus. Find affordable medicine substitutes, save up to 50% on health products, up to 80% off on lab tests and free doctor consultations. Hypoglycemia can impair concentration ability and reaction time, this may place an individual and others at risk in situations where these abilities are important (e.g., driving or operating other machinery). It is given as an injection and your doctor or nurse will train you on the correct way to inject it. You should see insulin at the tip of the needle. Enjoy free home sample collection, view reports online and consult a doctor online for free. Do you have any questions related to Humalog Mix 50 100IU/ml Cartridge ? Animal reproduction studies have not been performed with HUMALOG Mix50/50. Never share a Humalog, Insulin Lispro Injection, Humalog Mix75/25, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, or Humalog Mix50/50 prefilled pen, cartridge, reusable pen compatible with Lilly 3 mL cartridges, or syringe between patients, even if the needle is changed. The used Pen may be discarded in your household trash after you have removed the needle. Humalog Mix 50 100IU/ml Cartridge is generally considered safe to use during pregnancy. Pentamidine may cause hypoglycemia, which may sometimes be followed by hyperglycemia. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. It is unsafe to consume alcohol with Humalog Mix 50 100IU/ml Cartridge. Always carry an extra Pen in case yours is lost or damaged. Insulin to be prescribed according to requirement by treating physician, Not online without personally seeing the patient. Your healthcare provider may prescribe a glucagon emergency kit so that someone else can give you glucagon if your blood sugar becomes too low (severe hypoglycemia) and you are unable to take sugar by mouth. If you have any questions or problems with your HUMALOG Mix50/50 KwikPen, contact Lilly at 1-800-LillyRx (1-800-545-5979) or call your healthcare provider for help. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Humalog Mix 50/50 Kwikpen Prices and Coupons. Humalog Mix 50 100IU/ml Cartridge should be used with caution in patients with kidney disease. Beta-adrenergic blockers may mask the symptoms of hypoglycemia in some patients. Humalog Mix 50 cartridges (for use with Autopen Classic or HumaPen pens) and Humalog Mix 50 KwikPen prefilled pens both contain biphasic insulin lispro. As with all therapeutic peptides, insulin administration may cause anti-insulin antibodies to form. Throw away all opened vials after 28 days of use, even if there is insulin left in the vial. Administration Should be taken with food: Administer w/in 15 min before or immediately after meals. are pregnant or plan to become pregnant. Alcohol, beta-blockers, clonidine, and lithium salts. Absorption — HUMALOG Mix50/50 has two phases of absorption. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Do not mix HUMALOG Mix50/50 with any other insulins or diluents. Elimination — Because of the absorption-rate limited kinetics of insulin mixtures, a true half-life cannot be accurately estimated from the terminal slope of the concentration versus time curve. Pull the needle out and apply gentle pressure over the injection site for several seconds. Other factors which may increase the risk of hypoglycemia include changes in meal pattern (e.g., macronutrient content or timing of meals), changes in level of physical activity, or changes to co-administered medication [see Drug Interactions (7)]. Inject immediately. Talk with your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant. There may be new information. Insulin lispro was not mutagenic in the following genetic toxicity assays: bacterial mutation, unscheduled DNA synthesis, mouse lymphoma, chromosomal aberration and micronucleus assays. HUMALOG ® MIX 50 ®: Jeringa tipo pluma (KwikPen ®) pre-cargada con cartucho de 3 ml con 300 unidades. Humalog (R) Mix 50 (R) 100U/ml x 5cart x 3ml Prospect Humalog (R) Mix 50 (R) 100U/ml x 5cart x 3ml. Continue holding your pen with the needle pointing up. To avoid medication errors between HUMALOG Mix50/50 and other insulins, instruct patients to always check the insulin label before each injection. Inject your insulin exactly as your healthcare provider has shown you. It’s a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduce the chances of developing serious complications of diabetes. Humalog Mix 50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection (rDNA ORIGIN) is a hormone produced in the body used to treat type 1 (insulin-dependent) diabetes in adults. Hold your Pen with the Needle pointing up. The Plunger will only reach the end of the cartridge when you have used all 300 units in the Pen. PROSPECT: INFORMATII PENTRU UTILIZATOR. The effects of age, race, obesity, pregnancy, smoking, or renal or hepatic impairment on the pharmacokinetics of HUMALOG Mix50/50 have not been studied. Inform patients that their ability to concentrate and react may be impaired as a result of hypoglycemia. Unopened vials can be used until the expiration date on the carton and label, if they have been stored in the refrigerator. Do not freeze. Humalog Mix 50/50 KwikPen may be used for type 1 or type 2 diabetes. I need a prescription to order insulin from 1mg. Carry a sugar source with you for immediate relief. Check your Pen to make sure you are taking the right type of insulin. Replace the Pen Cap by lining up the Cap Clip with the Dose Indicator and pushing straight on. Hypokalemia must be corrected appropriately [see Warnings and Precautions (5.3, 5.6)]. You may give other people a serious infection or get a serious infection from them. What are you using Humalog Mix Suspension for Injection for? The limited available data with HUMALOG Mix50/50 in pregnant women are insufficient to inform a drug-associated risk of adverse developmental outcomes. Patients with renal impairment may be at increased risk of hypoglycemia and may require more frequent HUMALOG Mix50/50 dose adjustment and more frequent glucose monitoring [see Warnings and Precautions (5.3)]. have an allergy to HUMALOG Mix50/50 or any of the ingredients in HUMALOG Mix50/50. are breastfeeding or plan to breastfeed. What should I tell my healthcare provider before taking Humalog Mix50/50? Resuspension is easier when the insulin has reached room temperature. If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered. There were no adverse effects on fetal viability, weight, and morphology at any dose. For more information on HUMALOG and insulin, go to www.humalog.com. Do not share your HUMALOG Mix50/50 KwikPen with other people, even if the needle has been changed. Please consult your doctor. Intensification or rapid improvement in glucose control has been associated with a transitory, reversible ophthalmologic refraction disorder, worsening of diabetic retinopathy, and acute painful peripheral neuropathy. The insulin device should be rotated in the palms of the hands ten times and inverted 180° ten times immediately before use to resuspend the insulin until it appears uniformly cloudy or milky. You may give other people a serious infection or get a serious infection from them. HUMALOG Mix50/50 starts acting fast. Always carry a quick source of sugar such as glucose tablets, hard candy or juice to treat low blood sugar. Symptomatic awareness of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system (e.g., beta-blockers) [see Drug Interactions (7)], or in patients who experience recurrent hypoglycemia. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal. They are used to treat diabetes.People with diabetes have a deficiency or absence of a hormone made by the pancreas called insulin. Poorly controlled diabetes increases the fetal risk for major birth defects, still birth, and macrosomia related morbidity. Adjustments in drug dosage, meal patterns, or exercise may be needed. In compliance with Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945, we don't process requests for Schedule X and other habit forming drugs. Side effects requiring immediate medical attention. In a combined fertility, perinatal, and postnatal study in male and female rats given 1, 5, and 20 units/kg/day subcutaneously (0.2, 0.8, and 3 times the human subcutaneous dose of 1 unit insulin lispro/kg/day, based on units/body surface area), mating and fertility were not adversely affected in either gender at any dose. mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids. Read this Instructions for Use before you start taking HUMALOG Mix50/50 and each time you get another KwikPen. Pregnant rats and rabbits were exposed to insulin lispro in animal reproduction studies during organogenesis. Without seeing the patient, can't priscribe medicine. Risk Mitigation Strategies for Hypoglycemia. Treatment with TZDs and HUMALOG Mix50/50 may need to be adjusted or stopped by your healthcare provider if you have new or worse heart failure. See the end of this Patient Information leaflet for a complete list of ingredients in Humalog Mix50/50. Unused Pens may be used until the expiration date printed on the Label, if the Pen has been kept in the refrigerator. Do not freeze. Pull off the Paper Tab from the Outer Needle Shield. It’s a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduce the chances of developing serious complications of diabetes. HUMALOG® (insulin lispro injection) is a rapid-acting human insulin analog used to lower blood glucose. Diabetes Ireland is delighted to hear of the Harvard success and congratulate Professor Melton and colleagues on figuring out the complex series of steps necessary to turn stem cells into beta cells. HUMALOG Mix50/50 KwikPens must never be shared between patients, even if the needle is changed. Insulin lispro has a fast onset of action while insulin lispro protamine has a prolonged duration of action. Sharing poses a risk for transmission of blood-borne pathogens [see Warnings and Precautions (5.1)]. Injection below the skin of the abdomen results in faster absorption as compared to other injection sites such as skin of the upper arms, thighs, or buttocks. Again pls advise Gulvasmet 50/500 vs Istamet 50/500. This may be associated with listlessness, confusion, palpitations, headache, sweating, and vomiting. Hypoglycemia is the most common adverse reaction associated with all insulin therapies, including HUMALOG Mix50/50. Managing blood glucose levels is an essential part of managing diabetes. Self-monitoring of blood glucose plays an essential role in the prevention and management of hypoglycemia. You should see insulin at the tip of the Needle. Generic Name: insulin lispro protamine 50% and insulin lispro 50% Got a health query? Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor for hypoglycemia. Together, they ensure rapid and consistent sugar control that helps control blood sugar levels for an entire day. Because some of these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. If you see blood after you take the needle out of your skin, press the injection site with a piece of gauze or an alcohol swab. Wipe the Rubber Seal with an alcohol swab. The primary activity of insulin including HUMALOG Mix50/50 is the regulation of glucose metabolism. The Pen will not let you dial more than the number of units left in the Pen. Nonmedicinal ingredients: dibasic sodium phosphate, glycerin, liquefied phenol, m-Cresol distilled, protamine sulfate, water for injection, and zinc oxide. Humalog Mix50 works very quickly and longer than soluble insulin. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site. Humalog Mix 50 100IU/ml Cartridge should be used with caution in patients with liver disease. Please rate Humalog Mix 50 100IU/ml Cartridge on price, Insulin Lispro (50%) + Insulin Lispro Protamine (50%), Lipodystrophy (skin thickening or pits at the injection site). Medically reviewed by Drugs.com. Data on a large number of exposed pregnancies do not indicate any adverse effect of insulin lispro (main constituent of Humalog Mix 50 100IU/ml Cartridge) on pregnancy or on the health of the fetus/newborn. However, fetal growth retardation was produced at the 20 units/kg/day-dose as indicated by decreased fetal weight and an increased incidence of fetal runts/litter. Drug: Insulin LISPRO Humalog® Mix50/50™ [50% insulin lispro protamine suspension and 50% insulin lispro injection, (rDNA origin)], three times daily at mealtime. drink alcohol or take prescription or over-the-counter medicines that contain alcohol. All products displayed on 1mg are procured from verified and licensed pharmacies. The following adverse reactions are discussed elsewhere in the labeling: Adverse Reactions from Clinical Studies or Postmarketing Reports. The following adverse reactions have been identified during post-marketing use of HUMALOG Mix50/50. For the Consumer. drive or use heavy machinery until you know how your insulin lispro product affects you. Pull off the Inner Needle Shield and throw it away. See Comparison of Insulins for specifics of meal timing. Use of insulin is contraindicated during the episodes of hypoglycemia. We comply with the HONcode standard for trustworthy health information -. Hold the Dose Knob in and. Insulin Lispro Protamine And Insulin Lispro. Insulin requirements may be decreased in the presence of drugs that increase insulin sensitivity or have hypoglycemic (glucose lowering) activity, such as oral antidiabetic agents, salicylates, sulfa antibiotics, certain antidepressants (monoamine oxidase inhibitors), angiotensin-converting-enzyme inhibitors, angiotensin II receptor blocking agents, beta-adrenergic blockers, inhibitors of pancreatic function (e.g., octreotide), and alcohol. The estimated background risk of miscarriage for the indicated population is unknown. Administration of insulin subcutaneously, including HUMALOG Mix50/50, has resulted in lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue) [see Dosage and Administration (2.1)] in some patients. Use HUMALOG Mix5050 KwikPen with caution in patients with visual impairment that may rely on audible clicks to dial their dose. Unscrew the capped Needle and throw it away (see. Rotate the injection site within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. If you have any questions or problems with your HUMALOG, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider for help. Inform patients that hypoglycemia is the most common adverse reaction with insulin. Humalog Mix50 Cartridge/Kwikpen Every 1 mL contains 100 units of human insulin analogue (insulin lispro mix; 50% insulin lispro and 50% insulin lispro protamine suspension). Instruct patients on the management of hypoglycemia [see Warnings and Precautions (5.3)]. If you wait to inject your dose, the insulin will need to be mixed again. Hyperglycemia has been reported with repeated insulin injections into areas of localized cutaneous amyloidosis; hypoglycemia has been reported with a sudden change to an unaffected injection site. Hypoglycemia can happen suddenly and symptoms may differ in each individual and change over time in the same individual. 3 mL single-patient-use KwikPen (prefilled). Do not use if discoloration or particulate matter is seen. Hi Kindly once consult to Dietitian for proper diet chart, Type || diabetes mellitus ischemic heart disease. The HUMALOG Mix50/50 KwikPen dials in 1 unit increments. Each milliliter of HUMALOG Mix50/50 injection contains insulin lispro 100 units, 0.19 mg protamine sulfate, 16 mg glycerin, 3.78 mg dibasic sodium phosphate, 2.20 mg Metacresol, zinc oxide content adjusted to provide 0.0305 mg zinc ion, 0.89 mg phenol, and Water for Injection. What are the possible side effects of HUMALOG Mix50/50? HUMALOG® Mix50/50™ and HUMALOG® Mix50/50™ KwikPen® are trademarks of Eli Lilly and Company. No adverse effects on embryo/fetal development were observed in offspring of rabbits exposed to insulin lispro at doses up to approximately 0.2 times the human subcutaneous dose of 1 unit/kg/day (see Data). Basingstoke, Hampshire: Eli Lilly and Company Limited; 1996 [revised 17 May 2018]. have heart failure or other heart problems. Comparison of Humalog Mix 50 With Human Insulin Mix 30 in Type 2 Diabetes Patients During Ramadan. HUMALOG Mix50/50 is a man-made insulin that is used to control high blood sugar in people with diabetes mellitus. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. These reactions usually resolve in a few days to a few weeks, but in some occasions, may require discontinuation. 3 mL single-patient-use pen (100 units/mL). Keep vials away from heat and out of direct light. Each pre-filled pen contains 300 units of insulin lispro in 3 ml suspension. Changing to humalog Mix 50 during Ramadan resulted in improvement in glycaemic control without increasing the incidence of hypoglycaemia. In a glucose clamp study performed in 30 healthy subjects, the onset of action and glucose-lowering activity of HUMALOG, HUMALOG Mix50/50, HUMALOG® Mix75/25™, and insulin lispro protamine suspension (ILPS) were compared (see Figure 1). Severe, life-threatening, generalized allergy, including anaphylaxis. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended. Hold the dose knob in and count to 5 slowly. Store unused Pens in the refrigerator at 36°F to 46°F (2°C to 8°C). You’ll do this twice daily to cover two meals. 50/50) to insulin lispro/insulin lispro protamine (Humalog Mix 50/50) • Convert unit-per-unit. Male fertility was not compromised when male rats given subcutaneous insulin lispro injections of 5 and 20 units/kg/day (0.8 and 3 times the human subcutaneous dose of 1 unit insulin lispro/kg/day, based on units/body surface area) for 6 months were mated with untreated female rats. insulin lispro protamine/insulin lispro (Rx) Brand and Other Names: Humalog Mix 50/50, Humalog Mix 50/50 Kwikpen, more... Humalog Mix 75/25, Humalog Mix … After mixing HUMALOG Mix50/50, inject your dose right away. The early phase represents insulin lispro and its distinct characteristics of rapid onset. Indianapolis, Indiana: Eli Lilly and Company; 2007. Figure 1 should be considered only as a representative example since the time course of action of insulin and insulin analogs, may vary in different individuals or within the same individual. There may be state or local laws about how you should throw away used needles and syringes. Increased frequency of glucose monitoring may be required when HUMALOG Mix50/50 is co-administered with these drugs. Do not reuse or share your syringes or needles with other people. Insulin lispro has the following primary structure: HUMALOG Mix50/50 vials and KwikPens contain a white and cloudy, sterile suspension of insulin lispro protamine suspension mixed with soluble insulin lispro for use as an injection. Do not share your needles or syringes with other people, even if the needle has been changed. Each KwikPen delivers 1 - … Always use a new disposable syringe or needle for each injection to prevent contamination. Put on a new needle and prime the pen. Sustained carbohydrate intake and observation may be necessary because hypoglycemia may recur after apparent clinical recovery. Severe hypoglycemia can cause seizures, may lead to unconsciousness, may be life-threatening, or cause death. If not, repeat the above procedure until contents are mixed. HUMALOG Mix50/50 can cause local injection site reactions including redness, swelling, or itching at the site of injection. Low blood sugar (hypoglycemia) is the most common side effect. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Metabolism — Human metabolism studies of HUMALOG Mix50/50 have not been conducted. Published studies with insulin lispro used during pregnancy have not reported an association between insulin lispro and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data). Humalog Mix50 consists of 50 % insulin lispro solution and 50 % insulin lispro protamine suspension. Indianapolis, IN 46285, USA, PACKAGE CARTON – HUMALOG Mix50/50 10 mL vial 1ct, PACKAGE CARTON – HUMALOG Mix50/50 KwikPen 5ct, insulin lispro protamine and insulin lispro injectable suspension, This device is recommended for use with Becton, Dickinson and Company's insulin pen needles, Read Insulin Delivery Device Instructions for Use. What is the difference between regular insulin and lispro (Humalog)? The Plunger only moves a little with each injection, and you may not notice that it moves. Humalog Mix 50 100IU/ml Cartridge contains Insulin Lispro Protamine, that has a prolonged duration of action as well as Insulin Lispro, that has a fast onset of action. Cada ml contiene 100 unidades: 50% (50 unidades) de insulina lispro y 50% (50 unidades) de insulina lispro protamina. Push the dose knob in until it stops and "0" is seen in the dose window. Know the type, strength, and amount of insulin you take. Insulin, including HUMALOG Mix50/50, may cause sodium retention and edema, particularly if previously poor metabolic control is improved by intensified insulin therapy. For priming, turn the dose knob to 2 units. Do not share your insulin device with other people, even if the needle has been changed. Hold your pen with the needle pointing up. Store in a refrigerator (2 - 8°C). Do not use if it looks clear or has any lumps or … How do you take Humalog Mix Suspension for Injection? Inform patients on the symptoms of hypersensitivity reactions and to seek medical attention if they occur [see Warnings and Precautions (5.5)]. HUMALOG Mix50/50 may cause serious side effects that can lead to death, including: severe allergic reaction (whole body reaction). Dose adjustment and increased frequency of glucose monitoring may be required when HUMALOG Mix50/50 is co-administered with these drugs. Graphs of mean glucose infusion rate versus time showed a distinct insulin activity profile for each formulation. Keep away from heat and light. Available for Android and iOS devices. Insulin lispro is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. HUMALOG Mix50/50 is a suspension that must be resuspended immediately before use. Last updated on April 1, 2020. There may be new information. The medication is made up of two different insulins: 50 percent intermediate-acting ( insulin lispro protamine) and 50 percent rapid-acting (insulin lispro). Using the outer needle cap, unscrew the needle and dispose of it safely. Humalog Mix 50/50 KwikPen is a combination medicine used to improve blood sugar control in adults with diabetes mellitus. Press the knob. Your doctor may tell you to use Humalog Mix50 KwikPen as well as a longer-acting insulin. Advise patients that changes in insulin regimen can predispose to hyperglycemia or hypoglycemia and that changes in insulin regimen should be made under close medical supervision [see Warnings and Precautions (5.2)]. In elderly patients with diabetes, the initial dosing, dose increments, and maintenance dosage should be conservative to reduce the risk of hypoglycemia [see Warnings and Precautions (5.3)]. Along with its needed effects, insulin lispro/insulin lispro protamine may cause some unwanted effects. [Accessed 08 Apr. All insulin products, including HUMALOG Mix50/50, cause a shift in potassium from the extracellular to intracellular space, possibly leading to hypokalemia. Localized reactions and generalized myalgias have been reported with the use of meta-cresol, which is an excipient in HUMALOG Mix50/50. It’s a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduce the chances of developing serious complications of diabetes. In Fischer 344 rats, a 12-month repeat-dose toxicity study was conducted with insulin lispro (a component of HUMALOG Mix50/50) at subcutaneous doses of 20 and 200 units/kg/day (approximately 3 and 32 times the human subcutaneous dose of 1 unit insulin lispro/kg/day, based on units/body surface area). Dispense in the original sealed carton with the enclosed Instructions for Use. Pushing the dose knob of the pen more slowly will make it easier to inject. Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA Copyright © 1999, 2019, Eli Lilly and Company. Store the Pen you are currently using at room temperature [up to 86°F (30°C)]. You may give other people a serious infection or get a serious infection from them. See. Humalog Mix50 KwikPen 100U/mL is a disposable pre-filled insulin pen. HUMALOG (insulin lispro injection), HUMALOG MIX25 (25% insulin lispro injection, 75% insulin lispro protamine suspension), and HUMALOG MIX50 (50% insulin lispro injection, 50% insulin lispro protamine suspension) are indicated for the treatment of patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis. are having an episode of low blood sugar (hypoglycemia). How to recognize your HUMALOG Mix50/50 KwikPen, Supplies you will need to give your injection, General information about the safe and effective use of your Pen. Beta-blockers, clonidine, guanethidine, and reserpine. Patients using HUMALOG Mix50/50 vials must never share needles or syringes with another person. HUMALOG Mix50/50 is contraindicated in patients who have had hypersensitivity reactions to HUMALOG Mix50/50 or any of its excipients [see Contraindications (4)]. 2019] (online) Available from: Insulin Lispro. Take it 15 minutes before a meal or within 20 minutes after starting a meal. Get medical help right away, if you have any of these signs or symptoms of a severe allergic reaction: low potassium in your blood (hypokalemia). You also get free health screening, premium doctor consultation and more, India's only LegitScript and ISO/IEC 27001 certified online healthcare platform. Insulin lispro protamine suspension is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. Patients with hepatic impairment may be at increased risk of hypoglycemia and may require more frequent HUMALOG Mix50/50 dose adjustment and more frequent glucose monitoring [see Warnings and Precautions (5.3)]. The median maximum pharmacologic effect of HUMALOG Mix50/50 after administration of a 0.3 unit/kg dose to healthy subjects occurred at 2 hours (range: 1-5 hours); glucose lowering activity was detectable for a median of 22 hours (range: 11 to 22 hours), which was the end of the clamp. Introduction. Experimental: Mix 50/50 3 doses of Mix 50/50 at mealtime. Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics.

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